As bombs fall on London, writer Agatha Christie considers selling a manuscript that will kill off her most famous creation.

Thirty years after starring in The Wizard of Oz (1939), beloved actress and singer Judy Garland (Renée Zellweger) arrives in London, England to perform sold-out shows at the Talk of the Town nightclub. While there, she reminisces with friends and fans and begins a whirlwind romance with musician Mickey Deans (Finn Wittrock), her soon-to-be fifth husband.

When nine-year-old Rob Cole felt the life force slipping from his mother's hand he could not foresee that this terrifying awareness of impending death was a gift that would lead him from the familiar life of 11th-century London to small villages throughout England and finally to the medical school at Ispahan. Though apprenticed to an itinerant barber surgeon, it is the dazzling surgery of a Jewish physician trained by the legendary Persian physician Avicenna that inspires him to accept his gift...